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Wednesday, August 21, 2013

Cannabis Can Prevent Cancer Caused by Cigarette Use, According to New Study


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A new study published by the journal J-Stage, and funded by the Ministry of Education, Culture, Sports, Science and Technology of Japan, has found that cannabinoids – whether THC, CBD or CBDV – were effective at blocking a certain enzyme which is known to cause cancer, and is produced in large amount when cigarettes are consumed.

“These results suggest that the pentylresorcinol structure in CBD may have structurally important roles in direct CYP1A1 inhibition, although the whole structure of CBD is required for overall inhibition”, according to researchers.
CYP1A1 is an enzyme which isn’t dangerous at low-levels, but is produced in large quantities when someone smokes cigarettes; at large doses, the enzyme has been linked to cancer.

Researchers state that; “Accordingly, CBD and its related compounds, which are potent inhibitors of CYP1A1 activity, would be useful as a lead compound in anticancer chemotherapy.”

Source:TheJointBlog


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Abstract:
Our recent work has shown that cannabidiol (CBD) exhibits the most potent direct inhibition of human cytochrome P450 1A1 (CYP1A1) among the CYP enzymes examined. However, the mechanism underlying this CBD inhibition remains to be clarified. Thus, to elucidate the structural requirements for the potent inhibition by CBD, the effects of CBD and its structurally related compounds on CYP1A1 activity were investigated with recombinant human CYP1A1. Olivetol, which corresponds to the pentylresorcinol moiety of CBD, inhibited the 7-ethoxyresorufin O-deethylase activity of CYP1A1; its inhibitory effect (IC50=13.8 µM) was less potent than that of CBD (IC50=0.355 µM). In contrast, d-limonene, which corresponds to the terpene moiety of CBD, only slightly inhibited CYP1A1 activity. CBD-2′-monomethyl ether (CBDM) and CBD-2′,6′-dimethyl ether inhibited CYP1A1 activity with IC50 values of 4.07 and 23.0 µM, respectively, indicating that their inhibitory effects attenuated depending on the level of methylation on the free phenolic hydroxyl groups in the pentylresorcinol moiety of CBD. Cannabidivarin inhibited CYP1A1 activity, although its inhibitory potency (IC50=1.85 µM) was lower than that of CBD. The inhibitory effects of Δ9-tetrahydrocannabinol and cannabielsoin (IC50s ≈10 µM), which contain a free phenolic hydroxyl group and are structurally constrained, were less potent than that of CBDM, which contains a free phenolic hydroxyl group and is rotatable between pentylresorcinol and terpene moieties. These results suggest that the pentylresorcinol structure in CBD may have structurally important roles in direct CYP1A1 inhibition, although the whole structure of CBD is required for overall inhibition.

FULL TEXT Link:
Structural Requirements for Potent Direct Inhibitionof Human Cytochrome P450 1A1by Cannabidiol: Role of Pentylresorcinol Moiety.

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